منابع مشابه
Inherited podocytopathies: FSGS and nephrotic syndrome from a genetic viewpoint.
Recent progress in defining the genetic basis of inherited glomerular disease has helped illuminate inadequacies in the way we describe many of these diseases. Too often, we talk about histologic patterns of injury, such as focal and segmental glomerulosclerosis (FSGS), as if they were diseases rather than descriptions of kidney biopsy specimens at particular points in time. Some patients “with...
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BACKGROUND Adrenocorticotropic hormone is being increasingly studied for treatment of various glomerulopathies, most notably membranous nephropathy. Less data are available regarding its use in idiopathic nephrotic syndrome (INS) secondary to minimal change disease (MCD) or focal segmental glomerulosclerosis (FSGS). We report here our experience with H.P. Acthar(®) Gel (repository corticotropin...
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Nephrotic syndrome (NS) in children includes a diverse group of diseases that range from genetic diseases without any immunological defects to causes that are primarily due to immunological effects. Recent advances in molecular and genomic studies have resulted in a plethora of genetic defects that have been localized to the podocyte, the basic structure that is instrumental in normal filtratio...
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The Notch signaling pathway comprises a family of transmembrane receptors, ligands, negative and positive modifiers, and transcription factors with regulatory activity in multiple cellular processes, including cell fate determination, development, differentiation, proliferation, apoptosis, and regeneration. A critical step in the activation of the Notch receptor is proteolytic cleavage of its i...
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T he dystroglycan complex, among other molecular complexes, attaches podocytes to the glomerular basement membrane (GBM). Regele et al. (1) previously localized -dystroglycan and -dystroglycan to the sole of the podocyte foot process. Furthermore, they found that in minimal-change nephropathy (MCN), protein expression was reduced by 75% for -dystroglycan and by 50% for -dystroglycan, whereas ex...
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ژورنال
عنوان ژورنال: Srpski arhiv za celokupno lekarstvo
سال: 2008
ISSN: 0370-8179,2406-0895
DOI: 10.2298/sarh08s4327b